Mother’s obesity during pregnancy increases the risk of heart disease in children – Study

We all know that the effect of a mother’s health on her unborn child is very deep, so it is necessary for women to pay more attention to health at the time of pregnancy. A mother who is obese during pregnancy can increase the risk of heart disease in her child. Scientists from the University of Colorado of America have made such a claim in their new study. According to the researchers, this is the first study in itself to show that maternal obesity causes molecular changes in the fetal heart and it alters gene expression related to nutrient metabolism, which subsequently It greatly increases the risk of heart-related problems in the child during the lifetime of the child.

The findings of this study are published in the Journal of Physiology. published Has happened. For this study, researchers from the University of Colorado, USA, used mice models, because they have similar human maternal physiology and the nutritional supply through the placenta.

How did the study happen?
During the research, rats were given high-fat food items as well as sugary drinks, which is equivalent to the human consumption of burgers, chips and fizzy (added gas) drinks. This diet is given to the rats until their weight becomes 25% more than their original normal weight, while 50 rats were given control food. After this, along with studying the embryos of mice, imaging techniques were also examined at 3, 6, 9 and 14 months after the birth of the child. These included scans such as echocardiogram and positron emission tomography (PET). Based on this, the genes, proteins and mitochondria of the children were analyzed.

What happened in the study
Researchers found that changes in cardiac metabolism in children largely depended on gender. The female fetus had 841 gene expression changes, while the male fetus had 764 gene expression changes. Only 10% of the modified genes were common in both sexes. Despite this, interestingly, disturbances in cardiac function were found in both male and female children born to obese mothers. However, there is a difference in the development of heart defects in both the sexes. Heart disturbances start earlier in male children, whereas in females the condition worsens with increasing age.

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Researchers say that differences in cardiovascular health and its functioning may be due to the hormone estrogen. Cardiovascular health is protected by high levels of estrogen in young age, while protection is lost when estrogen levels drop as we age. This difference on gender basis could not be understood on molecular basis.

what the experts say
The study’s main author, Dr. Owen Vaughan, of the University of Colorado, says, ‘Our study indicates that there is a process or mechanism between maternal obesity in the next generation of cardiometabolic disease. Is. This study is important in this sense, because obesity is increasing day by day in the human population and about one-third of women of childbearing age suffer from it. In such a situation, developing an understanding of the mechanism or mechanism of risk to children due to obesity can lead to finding a cure or prevention of cardiometabolic diseases.

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He further said, ‘In the direction of prevention, nutrition can be advised to mothers or children on the basis of their body mass index or a drug can be developed, which can correct the metabolism of the heart in the embryonic stage itself. to be able to work.

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